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KMID : 0369819940240040227
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Jorunal of Korean Pharmaceutical Sciences
1994 Volume.24 No. 4 p.227 ~ p.231
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Stability of Red Ginseng Saponin in Aqueous Solution
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이승진/Lee SJ
김신일/김길수/Kim SI/Kim KS
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Abstract
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The stability of red ginseng saponin in aqueous solution was studied with the acceleration test method. The degradation rate constant of ginsenoside Rb1, an index component of red ginseng saponin, was 2.371×10?4day?1 at 20?C, and the shelf-life was about 570 days. The pH-rate profile demonstrated that the most stable range was pH 6-8. Mannitol and benzyl alcohol, common excipients for injection, exerted no influence on the degradation reaction of ginsenoside Rb1.
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KEYWORD
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Stabilty, Red ginseng saponin, Ginsenoside Rb1, Benzyl alcohol, Mannitol
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